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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
17.88
Human Site:
T35
Identified Species:
28.1
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
T35
H
Q
L
L
G
S
S
T
L
N
K
P
N
S
G
Chimpanzee
Pan troglodytes
XP_522470
490
55999
T35
H
Q
L
L
G
S
S
T
L
N
K
P
N
S
G
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
T35
H
Q
L
L
G
N
L
T
L
N
K
A
N
S
G
Dog
Lupus familis
XP_538286
708
77776
T251
H
Q
L
L
G
S
L
T
L
N
R
A
N
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
T35
H
Q
L
L
G
S
L
T
Q
N
K
A
I
K
S
Rat
Rattus norvegicus
Q8CGU9
485
55603
T35
H
Q
I
L
G
G
L
T
Q
N
K
A
T
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
K8
M
I
E
D
K
E
N
K
D
H
S
S
E
G
G
Chicken
Gallus gallus
P70080
445
51121
K9
I
E
D
N
K
E
N
K
D
H
A
P
E
R
G
Frog
Xenopus laevis
Q92142
481
55388
I37
E
F
N
K
S
T
Y
I
K
I
E
D
N
K
E
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
L34
S
T
H
D
L
G
K
L
A
V
I
F
S
L
K
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
Q35
Q
Q
R
H
T
G
G
Q
M
S
R
R
P
S
F
Fruit Fly
Dros. melanogaster
P17276
452
51642
D16
D
K
P
T
R
V
E
D
S
A
Y
I
V
E
G
Honey Bee
Apis mellifera
XP_394674
508
57954
P35
I
H
K
S
S
D
I
P
M
V
E
R
K
S
N
Nematode Worm
Caenorhab. elegans
P90925
457
52111
A21
Y
A
M
E
S
Y
V
A
D
V
N
A
D
I
G
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
L34
A
A
D
R
R
A
L
L
R
R
M
S
S
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
80
80
N.A.
60
46.6
N.A.
6.6
13.3
6.6
0
13.3
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
86.6
86.6
N.A.
60
60
N.A.
20
33.3
20
6.6
33.3
13.3
20
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
0
0
0
7
0
7
7
7
7
34
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
14
14
0
7
0
7
20
0
0
7
7
0
7
% D
% Glu:
7
7
7
7
0
14
7
0
0
0
14
0
14
7
7
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
7
% F
% Gly:
0
0
0
0
40
20
7
0
0
0
0
0
0
7
54
% G
% His:
40
7
7
7
0
0
0
0
0
14
0
0
0
0
0
% H
% Ile:
14
7
7
0
0
0
7
7
0
7
7
7
7
7
0
% I
% Lys:
0
7
7
7
14
0
7
14
7
0
34
0
7
14
7
% K
% Leu:
0
0
34
40
7
0
34
14
27
0
0
0
0
7
0
% L
% Met:
7
0
7
0
0
0
0
0
14
0
7
0
0
0
0
% M
% Asn:
0
0
7
7
0
7
14
0
0
40
7
0
34
0
7
% N
% Pro:
0
0
7
0
0
0
0
7
0
0
0
20
7
0
0
% P
% Gln:
7
47
0
0
0
0
0
7
14
0
0
0
0
0
0
% Q
% Arg:
0
0
7
7
14
0
0
0
7
7
14
14
0
7
0
% R
% Ser:
7
0
0
7
20
27
14
0
7
7
7
14
14
47
14
% S
% Thr:
0
7
0
7
7
7
0
40
0
0
0
0
7
0
0
% T
% Val:
0
0
0
0
0
7
7
0
0
20
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
7
7
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _